Florfenicol, wani roba monofluorinated wanda aka samu daga thiamphenicol, wani sabon faffadan maganin kashe kwayoyin cuta na chloramphenicol don amfanin dabbobi, wanda aka samu nasarar ɓullo da shi a ƙarshen 1980s.
Game da cututtuka masu yawa, yawancin gonakin alade suna amfani da florfenicol akai-akai don hana ko magance cututtukan alade.Ko wace irin cuta ce, ko wane rukuni ko mataki, wasu manoma suna amfani da babban adadin florfenicol don magance ko rigakafin cututtuka.Florfenicol ba panacea bane.Dole ne a yi amfani da shi a hankali don cimma tasirin da ake so.Mai zuwa shine cikakken gabatarwa ga ma'anar amfani da florfenicol, yana fatan taimakawa kowa da kowa:
1. Antibacterial Properties na florfenicol
(1) Florfenicol magani ne na ƙwayoyin cuta mai faffadan ƙwayoyin cuta na ƙwayoyin cuta da ƙwayoyin cuta iri-iri na Gram-positive da korau da mycoplasma.Kwayoyin da ke da hankali sun haɗa da bovine da porcine Haemophilus, Shigella dysenteriae, Salmonella, Escherichia coli, Pneumococcus, Bacillus mura, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, da dai sauransu mafi kyawun sakamako mai hanawa.
(2) Gwaje-gwajen in vitro da in vivo sun nuna cewa ayyukansa na ƙwayoyin cuta sun fi na magungunan kashe ƙwayoyin cuta na yanzu, kamar thiamphenicol, oxytetracycline, tetracycline, ampicillin da quinolones da ake amfani da su a halin yanzu.
(3) Yin aiki da sauri, florfenicol na iya kaiwa ga maida hankali na warkewa a cikin jini sa'a 1 bayan allurar intramuscular, kuma ana iya kaiwa ga mafi girman ƙwayar ƙwayar cuta a cikin sa'o'i 1.5-3;dogon aiki, tasiri mai tasiri na ƙwayar magungunan jini za a iya kiyaye shi fiye da sa'o'i 20 bayan gudanarwa ɗaya.
(4) Yana iya shiga shingen jini-kwakwalwa, kuma tasirinsa akan cutar sankarau na dabba ba ya kama da na sauran magungunan kashe qwari.
(5) Ba shi da guba da illa idan aka yi amfani da shi a cikin adadin da aka ba da shawarar, yana shawo kan haɗarin aplastic anemia da sauran gubar da thiamphenicol ke haifarwa, kuma ba zai haifar da cutarwa ga dabbobi da abinci ba.Ana amfani da shi don kamuwa da cututtuka na sassa daban-daban na jiki da ƙwayoyin cuta ke haifar da dabbobi.Jiyya na aladu, ciki har da rigakafi da kuma kula da cututtuka na numfashi na kwayan cuta, meningitis, pleurisy, mastitis, cututtuka na hanji da ciwon bayan haihuwa a cikin aladu.
2. Kwayoyin cuta masu saurin kamuwa da cutar florfenicol da cutar florfenicol da aka fi so
(1) Cututtukan alade inda aka fi son florfenicol
Ana ba da shawarar wannan samfurin azaman maganin zaɓi don ciwon huhu na alade, ƙwayar cuta mai kamuwa da cuta ta ƙwayar cuta ta Haemophilus parasuis, musamman don maganin ƙwayoyin cuta masu jure wa fluoroquinolones da sauran maganin rigakafi.
(2) Ana kuma iya amfani da Florfenicol don maganin cututtukan alade masu zuwa
Hakanan za'a iya amfani dashi don magance cututtuka na numfashi wanda ya haifar da cututtuka daban-daban na Streptococcus ( ciwon huhu), Bordetella bronchiseptica (atrophic rhinitis), Mycoplasma pneumoniae (asthma alade), da dai sauransu;salmonellosis (piglet paratyphoid), colibacillosis (asthma piglet asthma) cututtuka na narkewa kamar su enteritis da zawo rawaya, zawo fari, piglet edema cuta) da sauran kwayoyin cuta.Ana iya amfani da Florfenicol don maganin waɗannan cututtuka na alade, amma ba magani ba ne don waɗannan cututtuka na alade, don haka ya kamata a yi amfani da shi da hankali.
3. Yin amfani da florfenicol mara kyau
(1) Adadin ya yi girma ko kuma ƙanƙanta.Wasu nau'ikan ciyarwa masu gauraya sun kai 400 mg/kg, kuma alluran alluran sun kai 40-100 mg/kg, ko ma sama da haka.Wasu suna kanana kamar 8 ~ 15mg/kg.Manyan allurai suna da guba, kuma ƙananan allurai ba su da tasiri.
(2)Lokaci yayi tsayi da yawa.Wasu dogon lokaci babban adadin amfani da kwayoyi ba tare da kamewa ba.
(3) Amfani da abubuwa da matakai ba daidai ba ne.Shuka masu ciki da aladu masu kitso suna amfani da irin waɗannan kwayoyi ba tare da nuna bambanci ba, suna haifar da guba ko ragowar ƙwayoyi, wanda ke haifar da samarwa da abinci mara kyau.
(4) Rashin daidaituwa.Wasu mutane sukan yi amfani da florfenicol a hade tare da sulfonamides da cephalosporins.Ko kimiyya ce kuma mai ma'ana ya cancanci bincike.
(5) Ciyarwa da gudanarwa ba a motsa su daidai gwargwado, wanda ke haifar da rashin tasirin magani ko guba.
4. Yin amfani da rigakafin florfenicol
(1) Wannan samfurin bai kamata a haɗa shi da macrolides (irin su tylosin, erythromycin, roxithromycin, tilmicosin, guitarmycin, azithromycin, clarithromycin, da dai sauransu), lincosamide (irin su lincomycin, clindamycin) da diterpenoid semi-synthetic hade da maganin rigakafi. lokacin da aka haɗa shi zai iya haifar da sakamako na gaba.
(2) Ba za a iya amfani da wannan samfurin a hade tare da amines β-lactone (irin su penicillins, cephalosporins) da fluoroquinolones (kamar enrofloxacin, ciprofloxacin, da sauransu), saboda wannan samfurin shine mai hana furotin na kwayan cuta mai saurin aiki da wakili na bacteriostatic. , na karshen shine maganin kashe kwayoyin cuta da sauri a lokacin kiwo.A karkashin aikin na farko, ana hana haɗin furotin na kwayan cuta da sauri, ƙwayoyin cuta suna daina girma da haɓaka, kuma tasirin bactericidal na karshen ya raunana.Sabili da haka, lokacin da magani yana buƙatar yin tasiri mai saurin haifuwa, ba za a iya amfani da shi tare ba.
(3) Ba za a iya haɗa wannan samfurin da sulfadiazine sodium don allurar cikin tsoka ba.Bai kamata a yi amfani da shi tare da magungunan alkaline ba yayin da ake gudanar da shi ta baki ko a cikin tsoka, don guje wa rubewa da gazawa.Hakanan bai dace da allurar cikin jijiya tare da tetracycline hydrochloride, kanamycin, adenosine triphosphate, coenzyme A, da sauransu, don guje wa hazo da raguwa a cikin inganci.
(4) Ana iya haifar da lalatawar tsoka da necrosis bayan allurar ciki.Don haka, ana iya yin allura ta wani wuri a cikin zurfin tsokoki na wuyansa da duwawu, kuma bai dace a sake yin allura a wuri ɗaya ba.
(5) Domin wannan samfurin na iya samun embryotoxicity, ya kamata a yi amfani da shi tare da taka tsantsan a cikin masu ciki da masu shayarwa.
(6) Lokacin da zafin jikin alade mara lafiya ya yi yawa, ana iya amfani da shi tare da antipyretic analgesics da dexamethasone, kuma tasirin ya fi kyau.
(7) A cikin rigakafi da kuma kula da ciwon numfashi na porcine (PRDC), wasu mutane suna ba da shawarar hada amfani da florfenicol da amoxicillin, florfenicol da tylosin, da florfenicol da tylosin.Ya dace, saboda daga ra'ayi na pharmacological, ba za a iya amfani da su biyu a hade ba.Koyaya, ana iya amfani da florfenicol tare da tetracyclines kamar doxycycline.
(8) Wannan samfurin yana da guba na hematological.Ko da yake ba zai haifar da ɓarnar kasusuwa aplastic anemia ba, hanawa mai jujjuyawa na erythropoiesis da ke haifar da shi ya fi na chloramphenicol (nakasassu).An contraindicated a cikin lokacin alurar riga kafi ko dabbobi masu tsananin rashin ƙarfi.
(9) Yin amfani da dogon lokaci na iya haifar da rikicewar narkewar abinci da ƙarancin bitamin ko alamun kamuwa da cuta.
(10) A wajen yin rigakafi da magance cutar alade, a kula, sannan a yi amfani da maganin daidai gwargwado da tsarin magani, kuma kada a yi amfani da shi don guje wa illa.
(11) Ga dabbobin da ke fama da gazawar koda, yakamata a rage adadin ko kuma a tsawaita lokacin gudanarwa.
(12) Idan akwai ƙananan zafin jiki, an gano cewa yawan rushewar yana jinkirin;ko maganin da aka shirya yana da hazo na florfenicol, kuma kawai yana buƙatar zafi kaɗan (ba fiye da 45 ℃) don narke duk da sauri.Maganin da aka shirya yana da kyau a yi amfani da shi a cikin sa'o'i 48.
Lokacin aikawa: Agusta-09-2022