Florfenicolwani sinadari ne na roba wanda aka samo daga thiamphenicol, tsarin kwayoyin halitta shine C12H14Cl2FNO4S, foda mai launin fari ko fari, mara wari, yana narkewa kaɗan a cikin ruwa da chloroform, yana narkewa kaɗan a cikin glacial acetic acid, yana narkewa a cikin Methanol, ethanol. Sabon maganin rigakafi ne mai faɗi na chloramphenicol don amfanin dabbobi, wanda aka haɓaka cikin nasara a ƙarshen shekarun 1980.
An fara tallata shi a Japan a shekarar 1990. A shekarar 1993, Norway ta amince da maganin don magance cututtukan salmon na kudan zuma. A shekarar 1995, Faransa, Burtaniya, Austria, Mexico da Spain sun amince da maganin don magance cututtukan ƙwayoyin cuta na numfashi na shanu. An kuma amince da amfani da shi a matsayin ƙarin abinci ga aladu a Japan da Mexico don hana da kuma magance cututtukan ƙwayoyin cuta a cikin aladu, kuma China ta amince da maganin yanzu.
Maganin rigakafi ne, wanda ke samar da tasirin bacteriostatic mai faɗi ta hanyar hana ayyukan peptidyltransferase, kuma yana da faffadan bakan maganin kashe ƙwayoyin cuta, gami da nau'ikan daban-daban.Nau'in-tabbatacceda ƙwayoyin cuta marasa kyau da kuma mycoplasma. Kwayoyin cuta masu saurin kamuwa sun haɗa da shanu da alade Haemophilus,Ciwon hanji na Shigella, Salmonella, Escherichia coli, Pneumococcus, Influenza bacillus, Streptococcus, Staphylococcus aureus, Chlamydia, Leptospira, Rickettsia, da sauransu. Wannan samfurin zai iya yaɗuwa cikin ƙwayoyin cuta ta hanyar narkewar lipid, galibi yana aiki akan ƙaramin rukunin ribosome na ƙwayoyin cuta na 70s na 50s, yana hana transpeptidase, yana hana haɓakar peptidase, yana hana samuwar sarƙoƙin peptide, don haka yana hana haɗa furotin, yana cimma manufar maganin ƙwayoyin cuta. Ana shan wannan samfurin cikin sauri ta hanyar shan ta baki, yana yaɗuwa sosai, yana da tsawon rabin rai, yawan shan magunguna a jini, da kuma tsawon lokacin kula da magunguna a jini.
A cikin 'yan shekarun nan, ƙananan gonakin aladu da matsakaitan girma sun yi amfani da florfenicol don magani ba tare da la'akari da yanayin aladu ba, kuma sun yi amfani da florfenicol a matsayin maganin sihiri. A gaskiya ma, wannan yana da haɗari sosai. Yana da kyakkyawan tasiri ga cututtukan aladu waɗanda ƙwayoyin cuta masu kama da Gram-positive da negative da mycoplasma ke haifarwa, musamman bayan haɗar florfenicol da doxycycline, tasirin yana ƙaruwa, kuma yana da tasiri wajen magance sarkar rhinitis na alade. Cocci, da sauransu suna da kyakkyawan sakamako na warkarwa.
Duk da haka, dalilin da ya sa yake da haɗari a yi amfani da florfenicol akai-akai shine saboda akwai illoli da yawa na florfenicol, kuma amfani da florfenicol na dogon lokaci yana haifar da illa fiye da amfani. Misali, bai kamata abokan alade su yi watsi da waɗannan abubuwan ba.
1. Idan akwai cututtukan ƙwayoyin cuta kamar zazzabin alade mai launin shuɗi a gonar alade, amfani da florfenicol don magani sau da yawa yakan zama sanadin waɗannan cututtukan ƙwayoyin cuta, don haka idan cututtukan da ke sama sun kamu kuma suka biyo baya Idan kun kamu da wasu cututtukan alade, kada ku yi amfani da florfenicol don magani, zai ƙara ta'azzara cutar.
2. Florfenicol zai yi katsalandan ga tsarin jininmu kuma ya hana samar da jajayen ƙwayoyin jini a cikin ƙashi, musamman idan aladu masu shayarwa suna da mura ko kumburi a gidajen abinci. Launin gashin alade ba shi da kyau, gashi mai soyayye, amma kuma yana nuna alamun rashin jini, zai kuma sa aladen ya daina cin abinci na dogon lokaci, yana samar da tauri.
3. Florfenicol yana da guba ga tayin. Idan ana yawan amfani da florfenicol a lokacin daukar ciki a cikin shuka, aladu da suka biyo baya ba za su yi aiki ba.
4. Amfani da flurfenicol na dogon lokaci zai haifar da matsalolin ciki da gudawa a cikin aladu.
5. Yana da sauƙi a haifar da kamuwa da cuta ta biyu, kamar cututtukan fata na exudative da kamuwa da cutar staphylococcus ke haifarwa a cikin aladu ko kamuwa da cuta ta biyu ta wasu cututtukan fata na fungal.
A taƙaice dai, bai kamata a yi amfani da florfenicol a matsayin magani na gargajiya ba. Idan muka yi amfani da wasu magungunan kashe ƙwayoyin cuta marasa tasiri kuma suna cikin ma'ana iri ɗaya (expel virus), za mu iya amfani da florfenicol da doxycycline a gefe. Ana amfani da acupuncture don magance cututtuka masu wahala, kuma ba a ba da shawarar yin amfani da shi a wasu yanayi ba.
Lokacin Saƙo: Yuli-14-2022