Masu bincike daga Sashen Biochemistry a Cibiyar Kimiyya ta Indiya (IISc) sun gano hanyar da aka dade ana nema.don daidaita haɓakar tsire-tsire na ƙasa kamar bryophytes (ƙungiyar da ta haɗa da mosses da liverworts) waɗanda aka riƙe a cikin tsire-tsire masu fure.
Binciken, wanda aka buga a cikin mujallar Nature Chemical Biology, ya mayar da hankali kan ka'idojin da ba na canonical na furotin DELLA ba, babban mai kula da ci gaban girma wanda ke hana rarraba cell a cikin embryophytes (tsiran ƙasa).
Abin sha'awa shine, bryophytes, tsire-tsire na farko da suka bayyana akan ƙasa kimanin shekaru miliyan 500 da suka wuce, basu da mai karɓar GID1, duk da samar da phytohormone GA. Wannan ya haifar da tambayar yadda aka tsara girma da bunƙasa waɗannan tsire-tsire na ƙasa.
Yin amfani da liverwort Marchantia polymorpha a matsayin tsarin samfuri, masu binciken sun gano cewa waɗannan tsire-tsire na farko suna amfani da enzyme na musamman, MpVIH, wanda ke samar da inositol pyrophosphate (InsP₈), don rushe DELLA ba tare da sa hannu ba.gibberellic acid.
Masu binciken sunyi amfani da tsarin CRISPR-Cas9 don fitar da kwayar halitta ta hanyar VIH enzyme, yana tabbatar da rawar da ya taka. Tsire-tsire da ba su da aikin VIH sun nuna mummunan lahani na ci gaba da rashin daidaituwa, kamar ƙananan ganye, raunin radial girma, da rashin calyxes. An kawar da waɗannan lahani ta hanyar gyara kwayoyin halittar shuka don samar da ƙarshen ƙarshen (N-terminus) na VIH enzyme. Yin amfani da dabarun chromatography na ci gaba, ƙungiyar ta gano cewa N-terminus ya ƙunshi yankin kinase wanda ke haɓaka samar da InsP₈.
Masu binciken sun gano cewa DELLA ɗaya ce daga cikin makasudin salon salula na VIH kinase. Bugu da ƙari kuma, sun lura cewa phenotypes na shuke-shuke na MpVIH-rauni sun kasance daidai da na M. polymorpha shuke-shuke tare da ƙarar DELLA.
"A wannan lokacin, mun yi farin cikin fahimtar ko an inganta kwanciyar hankali ko aiki na DELLA a cikin tsire-tsire marasa ƙarfi na MpVIH," in ji Priyanshi Rana, mawallafi na farko kuma ɗalibi a cikin rukunin bincike na Lahey. Daidai da hasashensu, masu binciken sun gano cewa hanawa DELLA na iya mayar da lahani ga ci gaban ci gaba da ci gaban tsiron mutant na MpVIH. Wadannan sakamakon sun nuna cewa VIH kinase yana daidaita tsarin DELLA mara kyau, yana inganta ci gaban shuka da ci gaba.
Bincike a cikin sunadaran DELLA ya samo asali ne tun lokacin juyin juya halin koren, lokacin da masana kimiyya cikin rashin sani suka yi amfani da damar su don ƙirƙirar nau'ikan dodanni masu yawan gaske. Ko da yake ba a fayyace cikakken bayanin aikinsu a lokacin ba, fasahar zamani ta baiwa masana kimiyya damar sarrafa ayyukan wadannan sunadaran ta hanyar injiniyan kwayoyin halitta, da kara yawan amfanin gona yadda ya kamata.
Lokacin aikawa: Oktoba-23-2025