Fuskantar pyrethroids na iya ƙara haɗarin kamuwa da cutar Parkinson saboda hulɗa da kwayoyin halitta ta hanyar tsarin garkuwar jiki.
Ana samun Pyrethroids a yawancin nau'ikan tsire-tsire na kasuwanci.magungunan kashe kwari na gidaDuk da cewa suna da guba ga kwari, hukumomin tarayya suna ɗaukar su a matsayin lafiyayyu ga hulɗa da mutane.
Bambancin kwayoyin halitta da kuma fallasa magungunan kashe kwari da ke haifar da cutar Parkinson sun bayyana suna yin tasiri ga haɗarin kamuwa da cutar. Wani sabon bincike ya gano alaƙa tsakanin waɗannan abubuwan haɗari guda biyu, yana nuna rawar da martanin garkuwar jiki ke takawa wajen ci gaban cututtuka.
Sakamakon ya shafi wani nau'inmagungunan kashe kwariana kiransa pyrethroids, waɗanda ake samu a yawancin magungunan kashe kwari na gida na kasuwanci kuma ana ƙara amfani da su a noma yayin da ake kawar da sauran magungunan kashe kwari. Duk da cewa pyrethroids suna da guba ga kwari, hukumomin tarayya gabaɗaya suna ɗaukar su a matsayin lafiya ga mutane.
Binciken shine na farko da ya danganta kamuwa da cutar Parkinson da haɗarin kwayoyin halitta, kuma ya buƙaci a ci gaba da nazarin, in ji babban marubuci Malu Tansi, Ph.D., mataimakiyar farfesa a fannin ilimin halittar jiki a Makarantar Magunguna ta Jami'ar Emory.
Bambancin kwayoyin halitta da ƙungiyar ta gano yana cikin yankin da ba na lambar kwayoyin halitta ba na kwayoyin halittar MHC II (babban rukunin kwayoyin halitta masu jituwa da juna a aji na II), wani rukuni na kwayoyin halitta da ke daidaita tsarin garkuwar jiki.
"Ba mu yi tsammanin samun wata alaƙa ta musamman da pyrethroids ba," in ji Tansey. "An san cewa fallasa ga pyrethroids cikin gaggawa na iya haifar da rashin aikin garkuwar jiki, kuma ana iya samun ƙwayoyin da suke aiki da su a cikin ƙwayoyin garkuwar jiki; Yanzu muna buƙatar ƙarin fahimtar yadda fallasa na dogon lokaci ke shafar tsarin garkuwar jiki kuma ta haka yana ƙara aikinsa." Haɗarin cutar Kinson."
"Akwai wata shaida mai ƙarfi da ke nuna cewa kumburin kwakwalwa ko kuma yawan aiki da tsarin garkuwar jiki na iya taimakawa wajen ci gaban cutar Parkinson. "Muna tsammanin abin da ke faruwa a nan shi ne cewa fallasa muhalli na iya canza martanin garkuwar jiki a wasu mutane, yana haifar da kumburi mai ɗorewa a kwakwalwa."
Don binciken, masu binciken Emory karkashin jagorancin Tansey da Jeremy Boss, Ph.D., shugaban Sashen Microbiology da Immunology, sun haɗu da Stuart Factor, Ph.D., darektan Cibiyar Cututtuka ta Emory's Comprehensive Parkinson, da Beate Ritz., MD, Jami'ar California, San Francisco. Tare da haɗin gwiwar masu binciken lafiyar jama'a a UCLA, Ph.D. Marubucin farko na wannan labarin shine George T. Kannarkat, MD.
Masu binciken UCLA sun yi amfani da wani rumbun adana bayanai na California wanda ya ƙunshi shekaru 30 na amfani da magungunan kashe kwari a fannin noma. Sun ƙayyade yadda ake fallasa su bisa ga nisan da ke tsakaninsu (aiki da adireshin gida) amma ba su auna matakan magungunan kashe kwari a jiki ba. Ana tsammanin ƙwayoyin Pyrethroids suna lalacewa da sauri, musamman idan aka fallasa su ga hasken rana, tare da rabin rayuwa a cikin ƙasa na kwanaki zuwa makonni.
Daga cikin mutane 962 daga Central Valley na California, wani nau'in MHC II da aka saba gani tare da shan magungunan kashe kwari na pyrethroid wanda ya fi matsakaicin matsakaici ya ƙara haɗarin kamuwa da cutar Parkinson. An gano nau'in kwayar halitta mafi haɗari (mutane da ke ɗauke da ƙwayoyin cuta guda biyu masu haɗari) a cikin kashi 21% na marasa lafiya da ke fama da cutar Parkinson da kuma kashi 16% na waɗanda ke da alamun cutar.
A cikin wannan rukunin, fallasa ga kwayar halitta ko pyrethroid kawai bai ƙara haɗarin kamuwa da cutar Parkinson ba sosai, amma haɗin gwiwar ya yi. Idan aka kwatanta da matsakaicin, mutanen da aka fallasa ga pyrethroids kuma suka ɗauki mafi girman haɗarin kwayar halittar MHC II suna da haɗarin kamuwa da cutar Parkinson sau 2.48 fiye da waɗanda ba su da isasshen kamuwa da cutar kuma suna ɗauke da mafi ƙarancin haɗarin kwayar halittar. Fuskantar wasu nau'ikan magungunan kashe kwari, kamar organophosphates ko paraquat, ba ya ƙara haɗari ta hanya ɗaya.
Manyan nazarin kwayoyin halitta, ciki har da Factor da marasa lafiyarsa, sun taɓa danganta bambancin kwayoyin halitta na MHC II da cutar Parkinson. Abin mamaki, bambancin kwayoyin halitta iri ɗaya yana shafar haɗarin cutar Parkinson ta hanyoyi daban-daban a cikin Caucasians/Turai da mutanen China. Kwayoyin halittar MHC II sun bambanta sosai tsakanin mutane; saboda haka, suna taka muhimmiyar rawa wajen zaɓar dashen gabobi.
Wasu gwaje-gwaje sun nuna cewa bambance-bambancen kwayoyin halitta da ke da alaƙa da cutar Parkinson suna da alaƙa da aikin ƙwayoyin rigakafi. Masu bincike sun gano cewa daga cikin marasa lafiya 81 da ke fama da cutar Parkinson da kuma waɗanda ke kula da su a Turai daga Jami'ar Emory, ƙwayoyin rigakafi daga mutanen da ke da bambancin kwayoyin halitta na MHC II masu haɗari daga binciken California sun nuna ƙarin ƙwayoyin MHC.
Kwayoyin MHC suna ƙarƙashin tsarin "gabatar da kwayoyin halitta masu hana garkuwar jiki" kuma sune ƙarfin da ke kunna ƙwayoyin T kuma yana jan hankalin sauran tsarin garkuwar jiki. Ana ƙara yawan bayyanar MHC II a cikin ƙwayoyin da ke cikin kwanciyar hankali na marasa lafiya da ke fama da cutar Parkinson da kuma kula da lafiya, amma ana ganin ƙarin martani ga ƙalubalen garkuwar jiki a cikin marasa lafiya da ke fama da cutar Parkinson waɗanda ke da nau'ikan halittu masu haɗari;
Marubutan sun kammala da cewa: "Bayananmu sun nuna cewa alamun halitta na ƙwayoyin halitta, kamar kunna MHC II, na iya zama mafi amfani fiye da ƙwayoyin da ke narkewa a cikin plasma da ruwan cerebrospinal don gano mutanen da ke cikin haɗarin kamuwa da cuta ko don ɗaukar marasa lafiya don shiga cikin gwaje-gwajen magungunan immunomodulatory." " Gwaji."
Binciken ya samu goyon bayan Cibiyar Kula da Cututtukan Jijiyoyi da Shanyewar Jijiyoyi ta Ƙasa (R01NS072467, 1P50NS071669, F31NS081830), Cibiyar Kimiyyar Lafiyar Muhalli ta Ƙasa (5P01ES016731), Cibiyar Kimiyyar Lafiya ta Ƙasa (GM47310), Gidauniyar Iyalin Sartain Lanier, da Gidauniyar Michael J. Foxpa Kingson don Binciken Cututtuka.
Lokacin Saƙo: Yuni-04-2024