Bayyanawa ga pyrethroids na iya ƙara haɗarin cutar Parkinson saboda hulɗa da kwayoyin halitta ta hanyar tsarin rigakafi.
Ana samun Pyrethroids a yawancin kasuwancimagungunan kashe qwari na gida.Ko da yake suna neurotoxic ga kwari, ana ɗaukar su gabaɗaya amintattu ga hulɗar ɗan adam ta hukumomin tarayya.
Bambance-bambancen kwayoyin halitta da fallasa magungunan kashe qwari sun bayyana suna yin tasiri ga haɗarin cutar Parkinson.Wani sabon binciken ya gano hanyar haɗi tsakanin waɗannan abubuwan haɗari guda biyu, yana nuna rawar da martani na rigakafi ke da shi a cikin ci gaban cututtuka.
Sakamakon binciken yana da alaƙa da aji namagungunan kashe qwarida ake kira pyrethroids, wanda ake samu a yawancin magungunan kashe qwari na gida na kasuwanci kuma ana ƙara yin amfani da su a aikin gona yayin da sauran magungunan kashe qwari suka daina.Kodayake pyrethroids sune neurotoxic ga kwari, hukumomin tarayya gabaɗaya suna ɗaukar su lafiya ga bayyanar ɗan adam.
Binciken shi ne na farko da ya danganta bayyanar da cutar ta pyrethroid zuwa haɗarin kwayoyin halitta don cutar Parkinson kuma ya ba da tabbacin bin diddigin binciken, in ji babban marubucin Malu Tansi, Ph.D., mataimakin farfesa a fannin ilimin lissafi a Makarantar Medicine na Jami'ar Emory.
Bambancin jinsin da ƙungiyar ta gano yana cikin yankin da ba a saka lambar ba na MHC II (manyan histocompatibility complex class II), ƙungiyar kwayoyin halitta waɗanda ke daidaita tsarin rigakafi.
"Ba mu yi tsammanin samun takamaiman hanyar haɗi zuwa pyrethroids ba," in ji Tansey.“An san cewa matsananciyar kamuwa da cutar pyrethroid na iya haifar da tabarbarewar rigakafi, kuma ana iya samun ƙwayoyin da suke aiki da su a cikin ƙwayoyin rigakafi;Yanzu muna buƙatar ƙarin fahimta game da yadda bayyanar dogon lokaci ke shafar tsarin rigakafi kuma ta haka yana haɓaka aikinsa. ”Hadarin cutar Kinson."
“An riga an sami kwakkwarar shaidar cewa kumburin kwakwalwa ko tsarin garkuwar jiki na iya taimakawa wajen ci gaban cutar Parkinson."Muna tunanin abin da zai iya faruwa a nan shi ne bayyanar muhalli na iya canza martanin rigakafi a cikin wasu mutane, yana haɓaka kumburi na yau da kullun a cikin kwakwalwa."
Don binciken, masu binciken Emory karkashin jagorancin Tansey da Jeremy Boss, Ph.D., shugaban Sashen Microbiology da Immunology, sun haɗu da Stuart Factor, Ph.D., darektan Cibiyar Cutar Parkinson ta Emory, da Beate Ritz., MD, Jami'ar California, San Francisco.Tare da haɗin gwiwar masu binciken lafiyar jama'a a UCLA, Ph.D.Marubucin farko na labarin shine George T. Kannarkat, MD.
Masu binciken UCLA sun yi amfani da bayanan yanki na California wanda ya ƙunshi shekaru 30 na amfani da magungunan kashe qwari a aikin gona.Sun ƙaddara bayyanar da tazara (aikin wani da adiresoshin gida) amma ba su auna matakan magungunan kashe qwari a cikin jiki ba.Ana tsammanin Pyrethroids suna raguwa da sauri, musamman idan an fallasa su ga hasken rana, tare da rabin rayuwa a cikin ƙasa na kwanaki zuwa makonni.
Daga cikin batutuwa 962 daga Tsakiyar Tsakiyar California, bambance-bambancen MHC II na gama-gari wanda aka haɗe tare da matsakaicin matsakaicin kamuwa da magungunan kashe qwari na pyrethroid ya ƙara haɗarin cutar Parkinson.Mafi haɗari nau'i na kwayar halitta (mutane dauke da haɗari guda biyu) an samo su a cikin 21% na marasa lafiya da cutar Parkinson da 16% na sarrafawa.
A cikin wannan rukuni, bayyanar da kwayar halitta ko pyrethroid kadai bai ƙara haɗarin cutar Parkinson ba, amma haɗin ya yi.Idan aka kwatanta da matsakaita, mutanen da aka fallasa su ga pyrethroids kuma suna ɗaukar nau'in haɗari mafi girma na kwayar halittar MHC II suna da haɗarin haɓaka cutar Parkinson sau 2.48 fiye da waɗanda ke da ƙarancin fallasa kuma suna ɗaukar nau'in haɗarin mafi ƙasƙanci na kwayar.kasada.Fitar da wasu nau'ikan magungunan kashe qwari, irin su organophosphates ko paraquat, baya ƙara haɗari ta hanya ɗaya.
Manyan nazarin kwayoyin halitta, gami da Factor da marasa lafiyarsa, a baya sun danganta bambancin jinsin MHC II zuwa cutar Parkinson.Abin mamaki, bambance-bambancen kwayoyin halitta iri ɗaya yana shafar haɗarin cutar Parkinson daban-daban a cikin Caucasians/Turai da mutanen China.Kwayoyin halittar MHC II sun bambanta sosai tsakanin mutane;don haka suna taka muhimmiyar rawa wajen zabar dashen gabobi.
Wasu gwaje-gwajen sun nuna cewa bambance-bambancen jinsin da ke da alaƙa da cutar Parkinson suna da alaƙa da aikin ƙwayoyin cuta.Masu bincike sun gano cewa a cikin masu cutar Parkinson 81 da kuma ikon Turai daga Jami'ar Emory, ƙwayoyin rigakafi daga mutanen da ke da babban haɗari na MHC II jinsi daga binciken California sun nuna ƙarin kwayoyin MHC.
Kwayoyin MHC suna ƙarƙashin tsarin "gabatarwar antigen" kuma sune ƙarfin motsa jiki wanda ke kunna ƙwayoyin T kuma suna shiga sauran tsarin rigakafi.Maganar MHC II tana ƙaruwa a cikin ƙwayoyin quiescent na marasa lafiya na cutar Parkinson da kulawar lafiya, amma ana lura da mafi girman martani ga ƙalubalen rigakafi a cikin marasa lafiya na Parkinson tare da genotypes masu haɗari;
Marubutan sun kammala da cewa: “Bayananmu sun nuna cewa masu sarrafa kwayoyin halitta, irin su MHC II kunnawa, na iya zama mafi amfani fiye da kwayoyin da ke narkewa a cikin jini da ruwan cerebrospinal don gano mutanen da ke cikin hadarin kamuwa da cuta ko kuma daukar marasa lafiya don shiga cikin gwajin magungunan rigakafi.”"Gwaji."
Binciken ya sami goyan bayan Cibiyar Nazarin Ciwon Jiki da Ciwon Jiki (R01NS072467, 1P50NS071669, F31NS081830), Cibiyar Nazarin Kiwon Lafiyar Muhalli ta Kasa (5P01ES016731), Cibiyar Nazarin Ilimin Lafiya ta Kasa, Cibiyar Kimiyya ta Iyali da Janar Lantarki (GM47310), Sartain Foundation. Gidauniyar Michael J. Foxpa Kingson don Binciken Cututtuka.
Lokacin aikawa: Juni-04-2024