β-Triketone Nitisinone Yana Kashe Sauro Masu Juriya Ga Maganin Kwari Ta Hanyar Shan Fata | Kwari da Vectors

   Maganin kwarijuriya tsakanin cututtukan arthropods waɗanda ke yada cututtuka na noma, dabbobi da lafiyar jama'a yana haifar da babbar barazana ga shirye-shiryen kula da vector na duniya. Nazarin da aka yi a baya ya nuna cewa vectors masu tsotsar jini suna fuskantar yawan mace-mace lokacin da suke cin jini mai ɗauke da inhibitors na 4-hydroxyphenylpyruvate dioxygenase (HPPD), enzyme na biyu a cikin metabolism na tyrosine. Wannan binciken ya binciki ingancin β-triketone HPPD masu hana kamuwa da cuta akan nau'ikan cututtukan guda uku masu saurin kamuwa da cuta, ciki har da sauro da ke yada cututtuka na tarihi kamar malaria, kamuwa da cuta mai maimaitawa kamar dengue da Zika, da ƙwayoyin cuta masu tasowa kamar ƙwayoyin cuta Oropuche da Usutu.

Bambance-bambance tsakanin hanyoyin shafa maganin shafawa ta fuska, ta farji da kuma kwalba, hanyoyin shafawa, isar da maganin kwari da kuma tsawon lokacin da za a ɗauka.
Duk da haka, duk da bambancin mace-mace tsakanin New Orleans da Muheza a mafi girman allurai, duk sauran abubuwan da aka tara sun fi tasiri a New Orleans (wanda ake iya kamuwa da shi) fiye da Muheza (wanda ake iya jurewa) a cikin awanni 24.
Sakamakon bincikenmu ya nuna cewa nitisinone yana kashe sauro masu tsotsar jini ta hanyar hulɗar transtarsal, yayin da mesotrione, sulfotrione, da tepoxiton ba sa yi. Wannan hanyar kashewa ba ta bambanta tsakanin nau'ikan sauro masu saurin kamuwa da wasu nau'ikan magungunan kwari ba, gami da pyrethroids, organochlorines, da wataƙila carbamates. Bugu da ƙari, ingancin nitisinone wajen kashe sauro ta hanyar shan epidermal ba ya iyakance ga nau'ikan Anopheles ba, kamar yadda aka nuna ta hanyar ingancinsa akan Strongyloides quinquefasciatus da Aedes aegypti. Bayananmu suna goyon bayan buƙatar ƙarin bincike don inganta shan nitisinone, wataƙila ta hanyar haɓaka shan epidermal ko ƙara adjuvants. Ta hanyar sabon tsarin aikinsa na aiki, nitisinone yana amfani da halayen tsotsar jini na mata sauro. Wannan ya sa ya zama ɗan takara mai kyau don feshi na cikin gida da gidajen kwari masu ɗorewa, musamman a yankunan da hanyoyin magance sauro na gargajiya ba su da tasiri saboda saurin fitowar juriyar pyrethroid.