β-Triketone Nitisinone Yana Kashe Sauro Mai Jurewar Kwari ta Shayewar Fata | Parasites da Vectors

   Maganin kwarijuriya a tsakanin arthropods da ke yada cututtuka na aikin gona, dabbobi da lafiyar jama'a na haifar da babbar barazana ga shirye-shiryen kula da vector na duniya. Binciken da aka yi a baya ya nuna cewa masu shan jini na arthropod vectors suna samun yawan mace-mace yayin da suke shan jinin da ke dauke da masu hana 4-hydroxyphenylpyruvate dioxygenase (HPPD), enzyme na biyu a cikin metabolism na tyrosine. Wannan binciken yayi nazarin ingancin β-triketone HPPD inhibitors a kan masu saukin kamuwa da nau'in pyrethroid na manyan cututtuka guda uku, ciki har da sauro masu yada cututtuka na tarihi irin su zazzabin cizon sauro, cututtuka masu yawa kamar dengue da Zika, da ƙwayoyin cuta masu tasowa irin su Oropuche da Usutu.

Bambance-bambance tsakanin hanyoyin aikace-aikace na sama, tarsal da vial, hanyoyin aikace-aikace, isar da maganin kwari da tsawon lokacin aiki.
Koyaya, duk da bambancin mace-mace tsakanin New Orleans da Muheza a mafi girman kashi, duk sauran abubuwan da aka tattara sun fi tasiri a cikin New Orleans (mai saukin kamuwa) fiye da Muheza (mai jurewa) sama da awanni 24.
Sakamakonmu ya nuna cewa nitisinone yana kashe sauro masu shan jini ta hanyar hulɗar transtarsal, yayin da mesotrione, sulfotrione, da tepoxiton ba sa. Wannan hanyar kisan ba ta nuna bambanci tsakanin nau'ikan sauro masu hankali ko juriya sosai ga sauran nau'ikan maganin kwari, gami da pyrethroids, organochlorine, da yuwuwar carbamate. Bugu da ƙari kuma, tasirin nitisinone a cikin kashe sauro ta hanyar shayarwar epidermal ba'a iyakance ga nau'in Anopheles ba, kamar yadda aka nuna ta tasirinsa akan Strongyloides quinquefasciatus da Aedes aegypti. Bayananmu suna goyan bayan buƙatar ƙarin bincike don haɓaka sha na nitisinone, maiyuwa ta hanyar haɓaka sinadarai na sha na epidermal ko ƙari na adjuvants. Ta hanyar sabon tsarin aikin sa, nitisinone yana cin gajiyar dabi'ar tsotsar jini na sauro mata. Wannan ya sa ya zama ɗan takara mai ban sha'awa na sabbin hanyoyin feshi na cikin gida da kuma gidan yanar gizo na kwari mai dorewa, musamman a yankunan da hanyoyin magance sauro na gargajiya ba su da tasiri saboda saurin fitowar pyrethroid juriya.